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Molecular SIBLINGs in Health and Disease
2010 FASEB Conference on Osteopontin Biology
The Monday morning session (“Innate Immunity”) was chaired by Dr. Susan Rittling (The Forsyth Institute) and featured presentations by Drs. Susan Rittling, Toshimitsu Uede (Hokkaido University, Japan), Vily Panoutsakopoulou, (Biomedical Research Foundation Academy of Athens, Greece), and Paul Kuo (Duke University) as well as two short talks that were selected by the organizing committee from submitted abstracts. The theme of these talks addressed new research on OPN activity in inflammatory responses, innate immunity and pathogen surveilence. Following the afternoon poster session and dinner, the Monday evening session (“Adaptive Immunity”) was chaired by Dr.Johannes Weiss (University of Ulm, Germany) and featured presentations by Drs. Johannes M. Weiss, Harvey Cantor (Harvard Medial School), Mari Shinohara (Duke University), and Larry Steinman (Stanford University) with two short presentations selected by the organizing committee from submitted abstracts. The goal of this session was to convey novel research on OPN intracellular and immune signaling, activity in multiple sclerosis progression and skin immunity.

            The Tuesday morning session (“Cancer and Metastasis”) was chaired by Dr. B Yajun Guo (SMMU Cancer Institute, China) and featured talks by Ann Chambers (University of Western Ontario, Canada), George Weber (University of Cincinnati), Jian Zhao (SMMU Cancer Institute, China) and Vincent Castronovo (University of Liege, Belgium). The talks addressed new research on OPN as a biomarker of cancer detection, bone metastases, and disease progression and its potential molecular mechanisms of action. Following that afternoon’s poster session and dinner, the Tuesday evening session (“Vascular Biology and Inflammation”) was chaired by Dr. Cecilia Giachelli (University of Washington) and featured talks by Drs. Marta Scatena (University of Washington), Robert Taylor (Emory University), Chaeyoung Lee (Soongsil University, Korea), and Anna Hultgårdh-Nilsson (Lund University Sweden). These talks and the two short talks selected by the organizing committee from submitted abstracts addressed OPN biology in the vascular inflammation.

The Wednesday morning session (“OPN In Autoimmunity, Signaling And The Stress Response”) was chaired by Dr. David Denhardt (Rutgers University) and featured talks by Drs. Jianxin Dai (SMMU Cancer Institute, China), Hwyda Arafat, (Thomas Jefferson University), Kathryn Wang (Sanofi-Aventis US), Mohamed El-Tanani (Queen’s University Belfast, UK) as well as two short talks (selected from submitted abstracts) that addressed approaches to interfere with OPN-mediated autoimmunity and disease progression. Following that afternoon’s poster session and dinner, the Wednesday evening session (“Biomineralization”) was chaired by Graeme Hunter (University of Western Ontario, Canada) and featured presentations by Drs. Ann George  (University of Illinois at Chicago), Jeff Gorski (University of Missouri at Kansas City), Adele Boskey  (Weill Medical College of Cornell), Alain-Pierre Gadeau (INSERM, France). These presentations as well as the two short talks (selected from submitted abstracts) were presented the state of the art knowledge on OPN and SIBLING action in normal and ectopic mineralization.

            The Thursday morning session (“Bones and Teeth”), chaired by Dr. Masaki Noda (Tokyo Medical and Dental University, Japan), featured talks by Drs. Masaki Noda, Marc D. McKee (McGill University, Canada), Marian Young (NIDCR, N.I.H) as well as two short talks (selected from submitted abstracts) that describe the most recent research on OPN (and SIBLING) biology in skeletal tissue. Following that afternoon’s poster session and dinner, the evening session (“Receptor Interactions”) was chaired by Dr. David Haylock, (CSIRO, Australia) and featured talks by Drs. Susie Nilsson (CSIRO, Australia) and Goran Andersson (Karolinska Institute, Sweden). The final session is on Friday morning (“Structure Function”) and was chaired by Dr. Esben Sorensen (Aarhus University, Denmark) and had talks presented by Drs. Brian Christensen, Aarhus University, Denmark), Alka Jain (Johns Hopkins University), and Larry Fisher (NIDCR,NIH). All talks in this session addressed emerging understanding of OPN structural variants and differentially processed cleavage froms of OPN and their biological activity.