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Molecular SIBLINGs in Health and Disease
2012 FASEB Conference on Osteopontin

FASEB Science Research Conferences Osteopontin Biology
Saxtons River, Vermont

Co-Chairs:
Marta Scatena, University of Washington, Seattle, WA
Masaki Noda, University of Tokyo, Japan
Vice-Chair:
Mari Shinohara, Duke University, Durham, NC

Monday, August 6, 2012 

Session 1   

Osteopontin and Related Proteins: Structure and functions
Chair: Larry W. Fisher
NIDCR/NIH Craniofacial and Skeletal Disease branch

Speaker 1, Larry W. Fisher
NIDCR/NIH Craniofacial and Skeletal Disease branch“Introduction to the SIBLING family of proteins”

Speaker 2, Esben Sorensen, Protein Chemistry
Laboratory, Department of Molecular Biology, Aarhus
University, DK-8000 Aarhus, Denmark.   
Title: "Posttranslational modification of osteopontin" 

Speaker 3, Zofia von Marschall, Craniofacial and Skeletal Disease Branch, NIDCR/NIH
Title:
“DSPP in health and disease: Insights into trafficking of acidic proteins”

Speaker 4, Peter Rowe, The Kidney Institute, Kansas University Medical Center, Kansas City, KS
Title:
“The Chicken or the Egg: The SIBLINGs, PHEX and FGF23 unscrambled”

Speaker 5, from abstracts:
Br
ian Christensen, Eva Kläning, and Esben S. Sørensen, Protein Chemistry Laboratory, Department of Molecular Biology and Genetics, Aarhus University, Denmark.
Title:
 “C-terminal modification of osteopontin inhibits interaction with the αVβ3-integrin”

Speaker 6, from abstracts
Susan R Rittling, Stephen Skinner, Brian Christensen, and Esben Sorensen
The Forsyth Institute, Cambridge MA and Aarhus University, Aarhus, Denmark
Title: “Osteopontin in saliva: cross reactivity of anti- OPN antibodies with amyla
se” 

Session 2 

Osteopontin and Related Proteins: Expression regulation
Chair: Mohamed El-Tanani, Queens University, Center for Cancer Research and Cell Biology, 97 Lisburn Road, Belfast, BT9 7BL United Kingdom

Speaker 1, Paul C Kuo, Department of Surgery, Dept of Surgery, Loyola University Medical Center, Maywood, IL
Title: “Osteopontin induces mesench
ymal stem cell production of TGF-beta”

Speaker 2, Gopal C Kundu, National Center for Cell Science, Pune, India
Title:
"Role of Stroma and Tumor-derived Osteopontin in Regulation of Tumor Progression and Angiogenesis".

Speaker 3: Mohamed El-Tanani, Queens University, Center for Cancer Research and Cell Biology, 97 Lisburn Road, Belfast, BT9 7BL United Kingdom Title: “The role of osteopontin/RANGTP in cancer metastasis”

Speaker 4, Natalia Nieto, Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York
Title:
“Osteopontin and alcoholic liver disease”

Speaker 5, from abstracts
Jessica S. Donington, Chandra C Goparaju, Mark Slomiany, Nathalie Hirsch, Harvey I Pass
NYU School of Medicine, Thoracic Oncology Laboratory, Department of Cardiothoracic Surger
Title: “Exon 4 of osteopontin: A unique target to reduce malignant behavior in non-small cell lung cancer”

Speaker 6, from abstracts
Kivvi D Mello, 1,4 Tatiana M Tilli,1 Ana CS Ferreira, 2 João Luiz Wanderley, 3 Antônio Palumbo, 4 Rômulo M de Matos, 4 Claudete E Klumb, 2 Luiz E Nasciutti, 4 Etel RP Gimba, 1,5
1Programa de Carcinogênese Molecular and Programa de Pós Graduação Stricto Sensu em Oncologia do Instituto Nacional de Câncer (INCa), Rio de Janeiro-RJ, Brazil; 2Laboratório de Hemato- Oncologia Celular e Molecular, Programa de Pesquisa em Hemato-Oncologia Molecular-CGTC- INCa, Rio de Janeiro-RJ, Brazil; 3Faculdade de Medicina- Campus Macaé, Universidade Federal do Rio de Janeiro (UFRJ), Macáe-RJ, Brazil;); 4UFRJ, Instituto de Ciências Biomédicas, Programa de Pós Graduação em Ciências Morfológicas, Rio de Janeiro-RJ, Brazil and 5Departamento Interdisciplinar de Rio das Ostras (RIR), (PURO)/Universidade Federal Fluminense (UFF), Rio das Ostras-RJ, Brazil.
Title: “OPNb and OPNc spl
icing isoforms mediate prostate cancer cell pro-survival features through a PI3K/AKT and caspase 3 independent pathway”   

Tuesday, August 7, 2012 
Session 3 

Osteopontin and Related Proteins: Cancer development and progression
Chair: Lalita R. Shevde-Samant, University of South Alabama Cancer Research Institute Mobile, AL.

Speaker 1, Akeila Bellahcene, University of Liege, GIGA-Cancer, Pathology Tour, Liege, 4000 Belgium” 
Ti
tle: "Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo "
Speaker 2, Lalita R. Shevde-Samant, University of South Alabama Cancer Research Institute Mobile, AL
Ti
tle: “The OPNing Act in Cancer”

Speaker 3, Hwyda Arafat, Department of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA
Ti
tle: “Osteopotnin-RANGTPase in Pancreatic Ductal Adenocarcinoma”

Speaker 4, Neal S Fedarko, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland
Ti
tle: "Oteopontin and tumor associated macrophages"

Speaker 5, from abstracts
David Denhardt, Theodore Drashansky, Tom Kusch, Megha Rajpal, Kiran Patel, Monica Kadia, Camtu Nguyen, Chiann-Chyi Chen, Larry Steinman, Esben Sørensen, Yacov Ron
T
itle: “Biological Applications of anti-OPN Monoclonal Antibodies: Inhibition of Cancer Cell Growth”

Speaker 6, from abstracts
Pi-Ling Chang1,2,5, Yu-Hua Hsieh1, Chao-Chen Wang2, M. Margaret Juliana3, Craig Elmets2,5, Kang-Jey Ho4
1Department of Nutrition Sciences, 2Department of Dermatology, 3Department of Genetics, 4Department of Pathology, 5Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama USA
Title: “Osteopontin Facilitates Ultraviolet B-induced Squamous Cell Carcinoma Development”   

Session 4 

Osteopontin and Related Proteins: Inflammation and pathological angiogenesis

Chair: W. Robert Taylor,
Emory University School of Me
dicine, Medicine/Cardiology, 1639 Pierce Dr, Atlanta, GA

Speaker 1, Maria F. Gomez, Dept. of Clinical Sciences Lund University, Malmö, Swede
Ti
tle: "NFAT and osteopontin in vascular complications of diabetes"

Speaker 2, Alicia Lyle, Emory University School of Medicine, Atlanta GA
Title:
"The Role of Osteopontin in Post-Ischemic Neo- vascularization" 

Speaker 3, Krishna Singh, East Tennessee State University, Johnson City, TN
Title: “Osteopontin: role in cardiac myocyte apoptosis and myocardial remodeling”
Speaker 4, Johan M. Lorenzen, Hanover Medical School, Hannover, Germany
Title: "Regulation of acute and chronic kidney disease: role of osteopontin"
Speaker 5, from abstracts
Christa Caesar, 1, 2 Alicia N. Lyle, 2 W. Robert Taylor, 1, 2, 3
1
Wallace H Coulter, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University; 2 Division of Cardiology, Department of Medicine, Emory University; and 3 Veterans Affairs Medical Center, Atlanta, Georgia 
Title: “Cyclic Strain Induces Osteopontin Expression in Vascular Smooth Muscle via a Hydrogen Peroxide Dependent Mechanism”

Speaker 6, from abstracts
Peter P. Nghiem1, Joe N. Kornegay2, Kitipong Uaesoonstrachoon1, and Eric P. Hoffman1.1Department of Integrative Systems Biology, George Washington University School of Medicine, and Research Center for Genetic Medicine, Children’s National Medical Center, 111 Michigan Ave. NW, Washington, D.C. 20010; 2Department of Veterinary Integrative Biosciences (Mail Stop 4458), College of Veterinary Medicine, Texas A&M University, College Station, TX 77843- 4458.
Title: “Osteopontin is in a molecular network with AKT1 and myostatin (GDF8) regulating muscle size and response to damage” 
    Wednesday, August 8, 2012 
    Session 5

    Osteopontin and Related Proteins: Cadiovascular pathology
    Chair: Cecilia Giachelli, Department of Bioengineering, University of Washington, Seattle WA

    Speaker 1, Cecilia Giachelli, Department of Bioengineering, University of Washington, Seattle W
    Ti
    tle: "Role of Osteopontin in Vascular Calcification"

    Speaker 2, Meena Chellaiah, Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD
    Ti
    tle: “Osteopontin: Associations with VEGF expression and invasion of prostate cancer cells”
    Speaker 5, from abstracts
    Pe
    dersen TX (1,3), Madsen M (3), Junker N (3), Christoffersen C (1), Vikeså J (4), Bro S (2), Hultgårdh-Nilsson A (5), Nielsen LB (1,3)
    Dept.s of Clinical Biochemistry (1) and Nephrology (2), Rigshospitalet, Copenhagen, Denmark; Dept. of Biomedical Sciences, University of Copenhagen, Denmark (3); Center for genomic medicine, Rigshospitalet, Denmark (4); Dept. of Experimental Medical Science, University of Lund, Sweden (5)
    Ti
    tle: “Osteopontin accelerates uremic atherosclerosis” 

    Session 6 

    Osteopontin and Related Proteins: Bone mineralization and pathological calcification

    Chair: Adele L. Boskey,
    Hospital for Special Surgery, Musculoskeletal Integrity Program, 535 E 70th St, New York, NY

    Speaker 1, Harvey Goldberg, School of Dentistry and CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ont., Canada
    Ti
    tle: “Modulation of Mineral Formation by Osteopontin and Related Proteins”

    Speaker 2, Chunlin Qin, Department of Endodontics, the University of Texas-Houston Health Science Center Dental Branch, MD Anderson Blvd, Suit 307, Houston, TX
    Ti
    tle: “Dentin Matrix Protein 1 (DMP1) in Biomineralization and Phosphate Homeostasis"

    Speaker 3, Brian Foster, NIAMS/NIH Lab for Oral Connective Tissue Biology
    Title: “Roles
    of SIBLING proteins in periodontal development and regeneration”

    Speaker 4, Lauren Pachman, Department of Pediatrics, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Cure JM Center of Excellence in Juvenile Myositis Research, The Children's Memorial Research Center, Chicago, IL
    Title: “Osteopontin is a Component of Dystrophic Calcification in Children with Juvenile Dermatomyositis”   

    Thursday, August 9, 2012 
    Session 7 

    Osteopontin and Related Proteins: Innate and adaptive immunity
    Chair: Mari Shinohara, Duke University, Immunology, Duke Medical Center, 338 Jones Building, DUMC-3010, Durham, NC

    Speaker 1, Jianmei W. Leavenworth, Dana-Farber Cancer Institute and Department of Microbiology & Immunobiology, Division of Immunology, Harvard Medical School
    Title: “The contribution of intracellular Osteopontin to lymphocyte expansion”

    Speaker 2, Vily Panoutsakopoulou, Biomedical Research Foundation Academy of Athens, Greec
    Ti
    tle: “Immune tolerance and osteopontin”

    Speaker 3, Toshimitsu Uede, Hokkaido University, Institute for Genetic Medicine, Sapporo, Japan
    Title:
    “Tissue matricellular proteins regulates effector T cell egress from draining lymph nodes via alpha9 integrin-signaling”

    Speaker 4, from abstract
    Johannes M. Weiss, Lisa Borkner, Jan Scheurmann, Kamayani Singh, Karin Scharffetter-Kochanek and Denis F. Frenzel
    Department of Dermatology and Allergology, University of Ulm, Germany
    Title: Osteopontin is an important mediator in imiquimod induced Th17 driven psoriasis-like skin inflammation

    Speaker 5, from abstract
    Zhifei Shao, John Morser, and Lawrence Leung
    Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304
    Title:
    “Osteopontin Fragments Enhance Chemokine- induced Dendritic Cell Migration”

    Speaker 6, from abstracts
    Makoto Inoue1 and Mari L. Shinohara1,2
    1Department of Immunology, Duke University Medical Center, Durham, NC 27710
    2Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 
    Title: “Intracellular osteopontin plays a role to control excessive TNF-mediated inflammation through the CD40 signaling in macrophages”   
    Session 8 

    Osteopontin and Related Proteins: Auto-immune diseases and allergies
    Chair: Toshimitsu Uede, Hokkaido University, Institute for Genetic Medicine, Kita-15, Nishi-7, Kit-ku Sapporo 06-06815, Japan

    Speaker 1, Lawrence Leung, Stanford University School of Medicine, Stanford University
    Title:
    "Thrombin and Carboxypeptidase-B2 Cleavage of Osteopontin"

    Speaker 2, Mari Shinohara, Department of Immunology, Duke University
    Title: “Osteopontin
    in innate immunity”

    Speaker 4, from abstracts
    J. C. Yawe, M. Aouadi, P. Vangala, M. Tencerova, S. M. Nicoloro, J. Cohen, S. Amano, M.P. 
    Czech Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Tit
    le: “Targeted delivery of siRNA against osteopontin in adipose tissue macrophages improves insulin sensitivity in obese mice”

    Speaker 6, from abstracts
    Davina C M Simoes, Despina Mermiri, Evangelia Kourepini, Nikos Paschalidis and Vily Panoutsakopoulou
    Cellular Immunology Laboratory, Center for Basic Research I, Biomedical Research Foundation of the Academy of Athens
    Title: “Osteopontin exacerbates allergic airway Inflammation during house dust mite-induced experimental asthma”