Molecular SIBLINGs in Health and Disease

2015 International Osteopontin and Other SIBLING Proteins Conference
Organizers: Paul Kuo, Gopal Kundu, Mari Shinohara and Pi-Ling Chang
     October 8 to 11, Chicago, Illinois 

Day 1 Thursday- October 8th, 2015

14:00 Registration

19:30-19:45   Welcome

19:45-20:30   Keynote Speaker: David Denhardt; Denhardt's solution = stress & epigenetics

Session 1: Structure and Post-translational Modification

   Moderators   Esben Sorenson (Aarhus University) & Lawrence Leung (Stanford University)

20:30-20:55    Identification of transglutaminase 2 reactive residues and intramolecular cross-links in osteopontin. Esben Sorensen  (Aarhus University)


Day 2 Friday- Octorber 9th, 2015

08:25-08:30 Day 2 Opening remarks

Session 1 continued: Structure and Post-translational Modification

   Moderators   Esben Sorenson  (Aarhus University) & Lawrence Leung (Stanford University)

08:30-08:55    Structural preformation in osteopontin-Implication for ligand and receptor-binding. Robert Konrat (University of Vienna)

08:55-09:20    Phosphorylation of Osteopontin and the SIBLINGS by Fam20C: An atypical secretory pathway kinase. Carlyn Worby (University of California,  San Diego)

09:20-09:35    Characterization of the interaction between OPN and integrin.  Brian Christensen  (Aarhus University)


Session 2: Organ Function and Pathology

   Moderators   Natali Nieto (University of Illinois at Chicago), Gregory Johnson (Texas A&M University), Robert Taylor (Emory University), & Alicia lyle (Emory University)

09:45-10:10    OPN and its integrin receptors physically and functionally modify the uterus and placental to support pregnancy. Gregory Johnson (Texas A&M University)

10:10-10:30    Break

10:30-10:55    Osteopontin induces ductular reaction contributing to liver fibrosis. Natalia Nieto  (University of Illinois at Chicago)

10:55-11:20    The role of human OPN isoform in collateral formation.  Alicia Lyle  (Emory University)

11:20-11:35    OPN mediates fibrogenic effects of leptin and enhances NASH progression. Jason D Coombes (The institute of Hepatology, Foundation for Liver Research)

11:35-11:50    OPN ablation drives extramedullary hematopoiesis in the liver. Fernando Magdaleno (University of Illinois at Chicago)

11:50-12:05    Epigallocatechin-3-gallate upregulates mir-221 to inhibit OPN-dependent hepatocyte injury. M Arffa (Loyola University Chicago)

12:05-13:30    Lunch


Session 3: Tumorigenesis

   Moderators   Susan Rittling (The Forsyth Institute) & Pi-Ling Chang (University of Alabama at Birmingham)

13:30-13:55    The multifacet impact of OPN on lung adenocarcinoma development and dissemination. Georgios T. Stathopoulos (University of Patras & Ludwig-Maximilians Unversity and Helmholtz Zentrum M√ľnchen)

13:55-14:20    OPN: biomarker for the early detection of Hepatocellular carcinoma. Laura Berett (The University of Texas MD Anderson Cancer Center)

14:20-14:35    Hepatocyte derived OPN promotes the development of HCC. Xiaodong Ge (University of Illinois at Chicago)

14:35-14:55    OPN as an airway epithelial tumor promoter. Ioannis Psallidas (Oxford University)

14:55-15-15    Break


Session 4: Immune Surveillance

   Moderators   Vily Panoutsakopoulou (Biomedical Research Foundation of the Academy of Athens) & Amanda Brown (Johns Hopkins University)

15:15-15:40    Opposing roles of osteopontin in HIV-associated Neurocognitive disorder. Amanda Brown (Johns Hopkins University)

15:40-16:05    Role of OPN in solid and hematological malignancies. Claudia Chiodoni (Fondazione IRCCS Istituto Nazionale Tumori, Milan)

16:05-16:20    OPN regulates CXCR2 internalization and enhances neutrophil migration to sites of infection with endodontic pathogens. Susan Rittling  (The Forsyth Institute)

16:20-16:35    OPN generates IL-10 dependent immunological tolerance. Davina Simoes (Biomedical Research Foundation of the Academy of Athen)

16:35-18:00    Poster session

18:30-19:30    Welcome Dinner 


Day 3 Saturday- Octorber 10th, 2015


08:25-08:30 Day 3 Opening remarks

Session 5: Immunity

   Moderators  Mari Shinohara (Duke University) & Johanness Weiss (University of Ulm)

08:30-08:55    Intracellular OPN is essential for the differentiation of follicular helper and regulatory T cells. Jianmei Leavenworth (Harvard Medical School)

08:55-09:20    Both isoforms of OPN, secreted and intracellular, play a role in controlling hyperinflammation in innate immunity mediated T cells. Makoto Inoue (Duke University)

09:20-09:35    9-cis-retinoic acid modulates skin delayed type allergy through Treg inducing dendritic cells-a key function of OPN. Johannes Weiss (University of Ulm)

09:35-09:50    OPN in recall responses protects from allergy by arresting Th2 effector cell generation. Evangelia Kourepini (Biomedical Research Foundation of the Academy of Athens)


09:50-10:10 Break/Poster viewing


Session 6: Stem Cells and Tissue Regeneration

   Moderators  Susie Nilsson (Monash University) & Neal Fedarko (Johns Hopkins University)

10:10-10:35    OPN and regeneration of acutely injured skeletal muscle. Charlie Pagel (University of Melbourne)

10:35-11:05    Targeting the osteopontin: integrin interaction to harvest hematopoietic stem cells for marrow tranplants. Susie Nilsson (Monash University)

11:05-11:20    OPN neutralization abrogates the liver progenitor response and fibrogenic outcomes in mice. Jason D Coombes (The institute of Hepatology, Foundation for Liver Research)

11:20-11:35    Factors released by megakaryocytes thrombin cleave OPN to negatively regulate hemopoietic stem cell s Shen Y. Heazlewood (Monash University)

11:35-12:00    Business Meeting. Neal Fedarko (Johns Hopkins University)


Afternoon free


Day 4 Sunday-October 11th, 2015

08:25-08:30    Day 4 Opening remarks

Session 7: Cancer and Tumor microenvironment

 Moderators    Susan Rittling (The Forsyth Institute) & George Weber (University of Cincinnati)

08:30-08:55   Osteopontin and Myeloid Zinc Finger-1 Regulation of TGF-beta Expression in Cancer Associated Fibroblasts. Paul Kuo (Loyola University)

08:55-09:20   Therapeutic targeting of osteopontin in breast and other cancers. Gopal Kundu (National Centre for Cell Science)

09:20-09:35   OPN and Hh signalling: A mutually sustaining relationship. Lalita A Shevde ()

09:35-09:50   Cancer associated fibroblasts induction and maintenance are differentially regulated. Anai Kothari (Loyola University Medical Center)

09:50-10:10   Break


Session 8: Cancer and Targeting Strategies

  Moderators   Paul Kuo (Loyola University) & Gopal Kundu (National Centre for Cell Science)

10:10-10:35   OPN promotes leukemia cell dormancy in the bone marrow niche. Dorothy Sipkins (Duke University)

10:35-10:55   OPN splice variants in cancer progression. George Weber  (University of Cincinnati)

10:55-11:10   Tumor cell-derived OPN promotes lung metastasis via both cell autonomous and paracrine pathways. Ionna Giopanou (University of Patras)

11:10-11:25   OPN-c isoform promotes a mesenchymal phenotype in human cholangiocarcinoma. Jason D Coombes  (The institute of Hepatology, Foundation for Liver Research)

11:25-11:40   Closing Remarks