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 Osteopontin and Apoptosis

X. Xu et al., MiR-181a Promotes Apoptosis and Reduces Cisplatin Resistance by Inhibiting Osteopontin in Cervical Cancer Cells. Cancer Biother Radiopharm 34, 559 (2019). https://www.ncbi.nlm.nih.gov/pubmed/31436472

C. M. Sun et al., Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther 25, 1162 (2019). https://www.ncbi.nlm.nih.gov/pubmed/31436915

G. Zhao et al., Osteopontin contributes to effective neutrophil recruitment, IL-1beta production and apoptosis in Aspergillus fumigatus keratitis. Immunol Cell Biol 96, 401 (2018). https://www.ncbi.nlm.nih.gov/pubmed/29359350

W. Zhang et al., Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3beta Pathway Following Intracerebral Hemorrhage. Med Sci Monit 24, 1588 (2018). https://www.ncbi.nlm.nih.gov/pubmed/29550832

N. Mazaheri et al., Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol 38, 891 (2018). https://www.ncbi.nlm.nih.gov/pubmed/29110207

E. Im, C. Yeo, E. O. Lee, Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells. Life Sci 209, 259 (2018). https://www.ncbi.nlm.nih.gov/pubmed/30107166

C. Che et al., Osteopontin is essential for IL-1beta production and apoptosis in peri-implantitis. Clin Implant Dent Relat Res 20, 384 (2018). https://www.ncbi.nlm.nih.gov/pubmed/29446213

C. B. Bozal et al., Evaluation of apoptosis and osteopontin expression in osteocytes exposed to orthodontic forces of different magnitudes. Acta Odontol Latinoam 31, 110 (2018). https://www.ncbi.nlm.nih.gov/pubmed/30383075

K. Kawakami et al., Osteopontin attenuates acute gastrointestinal graft-versus-host disease by preventing apoptosis of intestinal epithelial cells. Biochem Biophys Res Commun 485, 468 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28192120

P. Jiang et al., Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCdelta-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol 44, 760 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28394420

T. Iida et al., Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases? Int J Mol Sci 19,  (2017). https://www.ncbi.nlm.nih.gov/pubmed/29267211

R. H. Huang et al., Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway. Cell Physiol Biochem 41, 1851 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28376477

R. Bhardwaj et al., Implication of hyperoxaluria on osteopontin and ER stress mediated apoptosis in renal tissue of rats. Exp Mol Pathol 102, 384 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28442375

M. Zahedpanah et al., Parthenolide Induces Apoptosis in Committed Progenitor AML Cell line U937 via Reduction in Osteopontin. Rep Biochem Mol Biol 4, 82 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27536701

S. Saleh et al., Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells. BMC Cancer 16, 359 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27282619

S. H. Lee et al., Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice. Oncotarget 7, 87219 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27888617

S. Dalal et al., Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK. Mol Cell Biochem 418, 1 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27262843

X. Li et al., Anti-nephrolithic potential of catechin in melamine-related urolithiasis via the inhibition of ROS, apoptosis, phospho-p38, and osteopontin in male Sprague-Dawley rats. Free Radic Res 49, 1249 (2015). https://www.ncbi.nlm.nih.gov/pubmed/26059739

H. Zhang et al., Osteopontin knockdown inhibits alphav,beta3 integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway. Cell Physiol Biochem 33, 991 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24714122

B. Zhang et al., Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis. Biochem Biophys Res Commun 452, 795 (2014). https://www.ncbi.nlm.nih.gov/pubmed/25201732

R. Tang et al., Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-alpha in inflammatory bowel disease. Inflamm Bowel Dis 20, 1950 (2014). https://www.ncbi.nlm.nih.gov/pubmed/25208103

C. Stemberger et al., Osteopontin is associated with decreased apoptosis and alphav integrin expression in lung adenocarcinoma. Acta Histochem 116, 222 (2014). https://www.ncbi.nlm.nih.gov/pubmed/23992637

S. Dalal et al., Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol 306, H1182 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24531809

K. Yumoto et al., Osteopontin Deficiency Suppresses Tumor Necrosis Factor-alpha-Induced Apoptosis in Chondrocytes. Cartilage 3, 79 (2012). https://www.ncbi.nlm.nih.gov/pubmed/26069621

Y. Wu et al., Breast cancer metastasis suppressor 1 regulates hepatocellular carcinoma cell apoptosis via suppressing osteopontin expression. PLoS One 7, e42976 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22927944

P. Long et al., A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. Eur J Neurosci 36, 2733 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22779921

R. Zhang et al., Requirement of Osteopontin in the migration and protection against Taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells. BMC Cell Biol 12, 11 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21406114

H. Pang et al., Knockdown of osteopontin chemosensitizes MDA-MB-231 cells to cyclophosphamide by enhancing apoptosis through activating p38 MAPK pathway. Cancer Biother Radiopharm 26, 165 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21539449

K. Matusan-Ilijas et al., Osteopontin expression correlates with nuclear factor-kappaB activation and apoptosis downregulation in clear cell renal cell carcinoma. Pathol Res Pract 207, 104 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21167650

M. Matsuura et al., Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. Oncol Rep 25, 41 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21109955

W. Chen et al., Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke 42, 764 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21273567

A. Zhang et al., Osteopontin silencing by small interfering RNA induces apoptosis and suppresses invasion in human renal carcinoma Caki-1 cells. Med Oncol 27, 1179 (2010). https://www.ncbi.nlm.nih.gov/pubmed/19921477

W. Yan et al., Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol 12, 765 (2010). https://www.ncbi.nlm.nih.gov/pubmed/20511184

W. Yan et al., [Effect of osteopontin silencing by lentivirus-mediated delivery of siRNA on glioma cell invasion and apoptosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26, 525 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19806573

J. Zhao et al., Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis. Gastroenterology 135, 956 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18555021

G. Song et al., Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. Exp Biol Med (Maywood) 233, 1537 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18849546

Y. Hao et al., Osteopontin improves in vitro development of porcine embryos and decreases apoptosis. Mol Reprod Dev75, 291 (2008). https://www.ncbi.nlm.nih.gov/pubmed/17874454

K. Fan et al., Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells. Arthritis Rheum 58, 2041 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18576331

M. Graessmann et al., Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. Oncogene 26, 2840 (2007). https://www.ncbi.nlm.nih.gov/pubmed/17160024

T. H. Burdo, M. R. Wood, H. S. Fox, Osteopontin prevents monocyte recirculation and apoptosis. J Leukoc Biol 81, 1504 (2007). https://www.ncbi.nlm.nih.gov/pubmed/17369493

K. H. Yoo et al., Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. Kidney Int 70, 1735 (2006). https://www.ncbi.nlm.nih.gov/pubmed/17003824

S. A. Khan et al., Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors. J Cell Biochem 85, 728 (2002). https://www.ncbi.nlm.nih.gov/pubmed/11968013

A. S. Weintraub et al., Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosis. Lab Invest 80, 1603 (2000). https://www.ncbi.nlm.nih.gov/pubmed/11092521

J. D. Noti, Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. Int J Oncol 17, 1237 (2000). https://www.ncbi.nlm.nih.gov/pubmed/11078811

V. Ophascharoensuk et al., Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis. Kidney Int 56, 571 (1999). https://www.ncbi.nlm.nih.gov/pubmed/10432396