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 Osteopontin and Calcification

S. Thanakun et al., Correlation of plasma osteopontin and osteocalcin with lower renal function in dental patients with carotid artery calcification and tooth loss. J Oral Biosci 61, 183 (2019). https://www.ncbi.nlm.nih.gov/pubmed/31400547

L. Grand Moursel et al., Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy. Brain Pathol 29, 793 (2019). https://www.ncbi.nlm.nih.gov/pubmed/30868685

B. Ganidagli et al., The relationship between serum osteopontin and FGF 23 levels with valvular calcification in hemodialysis patients. Clin Nephrol 91, 9 (2019). https://www.ncbi.nlm.nih.gov/pubmed/30369401

O. Ulutas et al., Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients. Int Urol Nephrol 50, 137 (2018). https://www.ncbi.nlm.nih.gov/pubmed/29134617

Q. Ge et al., Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification. Sci Rep 7, 40253 (2017). https://www.ncbi.nlm.nih.gov/pubmed/28091516

M. Sponder et al., Osteopontin is elevated in patients with mitral annulus calcification independent from classic cardiovascular risk factors. BMC Cardiovasc Disord 16, 132 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27283399

N. J. Paloian, E. M. Leaf, C. M. Giachelli, Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification. Kidney Int 89, 1027 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27083280

G. Wu et al., Correlation between calcification and bone sialoprotein and osteopontin in papillary thyroid carcinoma. Int J Clin Exp Pathol 8, 2010 (2015). https://www.ncbi.nlm.nih.gov/pubmed/25973097

J. J. Chen et al., C-type natriuretic peptide inhibiting vascular calcification might involve decreasing bone morphogenic protein 2 and osteopontin levels. Mol Cell Biochem 392, 65 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24710639

A. E. Berezin, A. A. Kremzer, Circulating osteopontin as a marker of early coronary vascular calcification in type two diabetes mellitus patients with known asymptomatic coronary artery disease. Atherosclerosis 229, 475 (2013). https://www.ncbi.nlm.nih.gov/pubmed/23880208

E. Stepien et al., Osteoprotegerin, but not osteopontin, as a potential predictor of vascular calcification in normotensive subjects. Hypertens Res 35, 531 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22278625

R. Sainger et al., Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease. Biomarkers 17, 111 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22191734

J. M. Lorenzen et al., Fetuin, matrix-Gla protein and osteopontin in calcification of renal allografts. PLoS One 7, e52039 (2012). https://www.ncbi.nlm.nih.gov/pubmed/23284864

W. L. Lau et al., Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int 82, 1261 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22932118

J. S. Shao et al., Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol 31, 1821 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21597007

S. Karakan et al., Circulating levels of osteopontin are related with calcification parameters in patients with renal transplantations. Transplant Proc 43, 562 (2011). https://www.ncbi.nlm.nih.gov/pubmed/21440761

S. Qi et al., Involvement of osteopontin as a core protein in craniopharyngioma calcification formation. J Neurooncol 98, 21 (2010). https://www.ncbi.nlm.nih.gov/pubmed/19902145

Y. Inagaki et al., High glucose levels increase osteopontin production and pathologic calcification in rat dental pulp tissues. J Endod 36, 1014 (2010). https://www.ncbi.nlm.nih.gov/pubmed/20478457

Y. Cai et al., Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway. Acta Pharmacol Sin 31, 1359 (2010). https://www.ncbi.nlm.nih.gov/pubmed/20802507

P. J. Yu et al., Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosis. J Thorac Cardiovasc Surg 138, 196 (2009).https://www.ncbi.nlm.nih.gov/pubmed/19577079

O. Uz et al., The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin. Turk Kardiyol Dern Ars 37, 397 (2009). https://www.ncbi.nlm.nih.gov/pubmed/20019453

H. Takada et al., Role of osteopontin in calcification in autoimmune pancreatitis. Dig Dis Sci 54, 793 (2009). https://www.ncbi.nlm.nih.gov/pubmed/18651220

M. M. El-Abbadi et al., Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int 75, 1297 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19322138

H. J. Cho, H. J. Cho, H. S. Kim, Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification. Curr Atheroscler Rep 11, 206 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19361352

M. Aryan et al., Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring. J Bone Miner Metab 27, 591 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19365701

S. Xue et al., Simple obesity is associated with reduced breast arterial calcification and increased plasma osteopontin level. Arch Med Res 39, 607 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18662593

N. Wang et al., Radial artery calcification in end-stage renal disease patients is associated with deposition of osteopontin and diminished expression of alpha-smooth muscle actin. Nephrology (Carlton) 13, 367 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18363643

F. A. Saad, E. Salih, M. J. Glimcher, Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification. J Cell Biochem 103, 852 (2008). https://www.ncbi.nlm.nih.gov/pubmed/17615552

G. Marhaug et al., Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis. Rheumatology (Oxford) 47, 1031 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18448482

W. Jahnen-Dechent et al., Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med (Berl) 86, 379 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18080808

F. Grases et al., Role of phytate and osteopontin in the mechanism of soft tissue calcification. J Nephrol 21, 768 (2008). https://www.ncbi.nlm.nih.gov/pubmed/18949733

N. Kuroda et al., Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin. Med Mol Morphol 40, 218 (2007). https://www.ncbi.nlm.nih.gov/pubmed/18085382

P. Schoenhagen, Osteopontin, coronary calcification, and cardiovascular events: future diagnostic and therapeutic targets for disease prevention? Eur Heart J 27, 766 (2006). https://www.ncbi.nlm.nih.gov/pubmed/16434412

J. Rivet et al., Cutaneous calcification in patients with end-stage renal disease: a regulated process associated with in situ osteopontin expression. Arch Dermatol 142, 900 (2006). https://www.ncbi.nlm.nih.gov/pubmed/16847207

B. C. Taylor et al., Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. Hum Genet 116, 525 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15744522

M. Y. Speer et al., Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Cardiovasc Res 66, 324 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15820201

R. G. Seipelt et al., Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification. J Thorac Cardiovasc Surg 129, 773 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15821643

R. Ohri et al., Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Calcif Tissue Int76, 307 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15812576

C. M. Giachelli et al., Regulation of vascular calcification: roles of phosphate and osteopontin. Circ Res 96, 717 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15831823

C. Makiishi-Shimobayashi et al., Localization of osteopontin at calcification sites of cholesteatoma: possible role as a regulator of deposition of calcium phosphate in the middle ear. Auris Nasus Larynx 31, 3 (2004). https://www.ncbi.nlm.nih.gov/pubmed/15041047

K. A. Lomashvili et al., Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J Am Soc Nephrol 15, 1392 (2004). https://www.ncbi.nlm.nih.gov/pubmed/15153550

Z. Aherrahrou et al., A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. Am J Pathol 164, 1379 (2004). https://www.ncbi.nlm.nih.gov/pubmed/15039225

K. Johnson et al., Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res 18, 994 (2003). https://www.ncbi.nlm.nih.gov/pubmed/12817751

S. A. Steitz et al., Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol161, 2035 (2002). https://www.ncbi.nlm.nih.gov/pubmed/12466120

M. Y. Speer et al., Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 196, 1047 (2002). https://www.ncbi.nlm.nih.gov/pubmed/12391016

Y. Nakazato et al., Calcification and osteopontin localization in the peritoneum of patients on long-term continuous ambulatory peritoneal dialysis therapy. Nephrol Dial Transplant 17, 1293 (2002). https://www.ncbi.nlm.nih.gov/pubmed/12105255

K. Nitta et al., Soluble osteopontin and vascular calcification in hemodialysis patients. Nephron 89, 455 (2001). https://www.ncbi.nlm.nih.gov/pubmed/11721165

A. P. Gadeau et al., Time course of osteopontin, osteocalcin, and osteonectin accumulation and calcification after acute vessel wall injury. J Histochem Cytochem 49, 79 (2001). https://www.ncbi.nlm.nih.gov/pubmed/11118480

M. Maki et al., Expression of osteopontin messenger RNA by macrophages in ovarian serous papillary cystadenocarcinoma: a possible association with calcification of psammoma bodies. Pathol Int 50, 531 (2000). https://www.ncbi.nlm.nih.gov/pubmed/10886734

S. Jono, C. Peinado, C. M. Giachelli, Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification. J Biol Chem 275, 20197 (2000). https://www.ncbi.nlm.nih.gov/pubmed/10766759

C. C. Canver et al., Association of osteopontin with calcification in human mitral valves. J Cardiovasc Surg (Torino) 41, 171 (2000). https://www.ncbi.nlm.nih.gov/pubmed/10901517

T. Wada et al., Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circ Res 84, 166 (1999). https://www.ncbi.nlm.nih.gov/pubmed/9933248

D. Proudfoot et al., Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression. Arterioscler Thromb Vasc Biol 18, 379 (1998). https://www.ncbi.nlm.nih.gov/pubmed/9514406

M. Shen et al., Osteopontin is associated with bioprosthetic heart valve calcification in humans. C R Acad Sci III 320, 49 (1997). https://www.ncbi.nlm.nih.gov/pubmed/9099263

L. A. Fitzpatrick et al., Diffuse calcification in human coronary arteries. Association of osteopontin with atherosclerosis. J Clin Invest 94, 1597 (1994). https://www.ncbi.nlm.nih.gov/pubmed/7929835

S. Hirota et al., Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification. Am J Pathol 143, 1003 (1993). https://www.ncbi.nlm.nih.gov/pubmed/8213995